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June 27, 2026PlateletsOpen Access

Hexokinase controls platelet activation and hemostasis

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Authors

LCLih T. CheahJKJawad S. KhalilBWBeth A. Webb

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Overview

Randomized trial investigates hexokinases' role in platelet activation and hemostasis, suggesting metabolic control mechanisms.

Key Points

  • This study aims to determine how hexokinases HK1 and HK2 affect platelet activation and hemostasis through metabolic pathways.
  • Evaluated platelet activation in response to thrombin and convulxin using pharmacological inhibitors 2DG and 3BP.
  • Measured glucose uptake, ATP production, and glycolytic activity following inhibition of hexokinases.
  • Assessed in vitro thrombus formation and in vivo bleeding times in mice treated with hexokinase inhibitors.
  • Activation-induced glucose uptake and glycolytic ATP production were significantly reduced with HK inhibition.
  • Platelet aggregation decreased but was not completely abolished, indicating metabolic flexibility during activation.
  • In vivo bleeding times were increased in mice treated with hexokinase inhibitors, highlighting HK's role in hemostasis.

Cite This Study

Cheah et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67aaaea7db3c1953f114https://doi.org/10.1080/09537104.2026.2692723
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