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June 27, 2026Communications MedicineOpen Access

Identifying and mitigating bias in multiple aspects of modern clinical research

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Authors

GTGeerthy ThambirajAAAntonis A. Armoundas

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Overview

Educational primer addresses bias in clinical research, highlighting methods to mitigate its impact.

Key Points

  • This research focuses on understanding and addressing bias in clinical research using large datasets.
  • Provides a consolidated framework outlining selection, information, and confounding biases.
  • Uses examples from traditional clinical trials and modern research.
  • Addresses bias across all stages of the research lifecycle.
  • Illustrated how selection bias distorts effect estimates in clinical research.
  • Demonstrated novel errors introduced by modern analytical methods if mismanaged.
  • Emphasized the importance of collaboration between clinical and data science teams in mitigating bias.

Cite This Study

Thambiraj et al. (2026) studied this question.

synapsesocial.com/papers/6a3f67e2aea7db3c1953f1bfhttps://doi.org/10.1038/s43856-026-01721-4
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  4. 4Study designs, levels of evidence, and scientific bias2024 · 3 citations
  5. 5When Bias Becomes Knowledge: How Sociodemographic Inequities Shape Medical AI2026