Key result
Elevated betatrophin linked to ~155% higher odds of hypertension, alongside low HDL-C but lower HOMA-IR.
Why the study?
The association between betatrophin and cardiometabolic risk factors, including insulin resistance, had not been established in adolescents.
Are elevated betatrophin levels associated with cardiometabolic risk factors in adolescents?
Cross-Sectional (n=306)
Are elevated betatrophin levels associated with cardiometabolic risk factors in adolescents?
Odds Ratio: 2.55 (95% CI 1.5–4.4)
p-value: p=<0.001
Elevated betatrophin levels in adolescents are associated with increased odds of high blood pressure and low HDL-cholesterol, but decreased odds of insulin resistance.
Should not guide adolescent cardiometabolic screening; hypothesis-generating and requires prospective validation.
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Alzamil et al. (2026) conducted a cross-sectional in Cardiometabolic risk factors (n=306). Elevated betatrophin was evaluated on High blood pressure (OR 2.55, 95% CI 1.5-4.4, p=<0.001). Elevated betatrophin levels were associated with increased odds of high blood pressure (OR 2.55; 95% CI 1.5-4.4) and low HDL-cholesterol, but decreased odds of elevated HOMA-IR.
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