What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Type 2 Diabetes (n=1603). Intervention: Plasma betatrophin/ANGPTL8 level vs. Lowest tertile of betatrophin. Primary outcome: Odds of having Type 2 Diabetes (highest vs lowest tertile of betatrophin) (OR 6.15, 95% CI 3.15-12.01, p=<0.0001).

June 16, 2015Scientific ReportsOpen Access

Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

Q: What are the key findings of this study?

Subjects in the highest tertile of plasma betatrophin had significantly higher odds of having Type 2 Diabetes (OR 6.15), although levels did not correlate with blood glucose or insulin resistance in diabetic subjects.

View Full Paper

Ask AI

Bookmark

Key result

Subjects in the highest tertile of plasma betatrophin had significantly higher odds of having Type 2 Diabetes (OR 6.15), although levels did not correlate with blood glucose or insulin resistance in diabetic subjects.

Population

1,603 adult South Asians and Arabs living in Kuwait, including 1,047 non-diabetic subjects and 556 subjects…

Design

Cross-sectional

Authors

MAMohamed Abu‐FarhaMubarak Al Kabeer Hospital JAJehad AbubakerDasman Diabetes Institute IAIrina Al‐KhairiDasman Diabetes Institute

Discussion

Member takes

Overview

Highest betatrophin levels associate with T2D but not glycemic parameters; hypothesis-generating for its role, requiring longitudinal validation.

Study Design

Type

Cross-Sectional (n=1,603)

Structured PICO

Population

1,603 adult South Asian and Arab subjects aged 18-65 living in Kuwait, including 556 with Type 2 Diabetes and 1,047 non-diabetic controls, evaluated in a cross-sectional study.

Comparator

Non-diabetic subjects

Outcome

Plasma betatrophin levels and their association with Type 2 Diabetes and metabolic risk factors (fasting blood glucose, HbA1c, HOMA-IR, lipid profile)surrogate

Main Result

Odds Ratio: 6.15 (95% CI 3.15–12.01)

p-value: p=<0.0001

Plasma betatrophin levels are significantly elevated in patients with Type 2 Diabetes but do not correlate with fasting blood glucose or insulin resistance in these individuals, raising questions about its functional role in the disease.

Limitations

The cross-sectional nature of the study cannot establish causality.
Differences in sample size and ethnic groups across studies may contribute to discrepancies with previous findings.
Cross-sectional nature that cannot establish causality

Cite This Study

Abu‐Farha et al. (2015) conducted a cross-sectional in Type 2 Diabetes (n=1,603). Plasma betatrophin/ANGPTL8 level vs. Lowest tertile of betatrophin was evaluated on Odds of having Type 2 Diabetes (highest vs lowest tertile of betatrophin) (OR 6.15, 95% CI 3.15-12.01, p=<0.0001). Subjects in the highest tertile of plasma betatrophin had significantly higher odds of having Type 2 Diabetes (OR 6.15), although levels did not correlate with blood glucose or insulin resistance in diabetic subjects.

synapsesocial.com/papers/6a843a91f3fc905d43bd818b https://doi.org/10.1038/srep10949

View Full Paper

Ask AI

Bookmark

June 16, 2015Scientific ReportsOpen Access

Higher plasma betatrophin/ANGPTL8 level in Type 2 Diabetes subjects does not correlate with blood glucose or insulin resistance

View Full Paper

Ask AI

Bookmark

Key result

Population

1,603 adult South Asians and Arabs living in Kuwait, including 1,047 non-diabetic subjects and 556 subjects…

Design

Cross-sectional

Authors

MAMohamed Abu‐FarhaMubarak Al Kabeer Hospital JAJehad AbubakerDasman Diabetes Institute IAIrina Al‐KhairiDasman Diabetes Institute

Discussion

Member takes

Overview

Highest betatrophin levels associate with T2D but not glycemic parameters; hypothesis-generating for its role, requiring longitudinal validation.

Study Design

Type

Cross-Sectional (n=1,603)

Structured PICO

Population

1,603 adult South Asian and Arab subjects aged 18-65 living in Kuwait, including 556 with Type 2 Diabetes and 1,047 non-diabetic controls, evaluated in a cross-sectional study.

Comparator

Non-diabetic subjects

Outcome

Plasma betatrophin levels and their association with Type 2 Diabetes and metabolic risk factors (fasting blood glucose, HbA1c, HOMA-IR, lipid profile)surrogate

Main Result

Odds Ratio: 6.15 (95% CI 3.15–12.01)

p-value: p=<0.0001

Limitations

The cross-sectional nature of the study cannot establish causality.
Differences in sample size and ethnic groups across studies may contribute to discrepancies with previous findings.
Cross-sectional nature that cannot establish causality

Cite This Study

synapsesocial.com/papers/6a843a91f3fc905d43bd818b https://doi.org/10.1038/srep10949

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark