Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 22, 2014The Journal of Clinical Endocrinology & Metabolism

Circulating Betatrophin Concentrations Are Decreased in Human Obesity and Type 2 Diabetes

View Full Paper
Ask AI
Bookmark
Share

Key result

Obesity and type 2 diabetes were associated with significantly decreased circulating betatrophin levels compared to lean normoglycemic individuals (13.5 vs 45.1 ng/mL; P<0.001).

Population

153 subjects including 75 obese normoglycemic, 30 obese with impaired glucose tolerance, 15 obese with type…

Design

Cross-sectional

Authors

JGJavier Gómez‐AmbrosiEPEider PascualVCVictoria Catalán

Discussion

Loading...

Member takes

Overview

No immediate clinical implications for betatrophin measurement; leaves open its utility as a cardiometabolic biomarker pending prospective validation.

Study Design

Type

Cross-Sectional (n=153)

Structured PICO

P
Population
153 subjects comprising 75 obese normoglycemic, 30 obese with impaired glucose tolerance, 15 obese with T2D, and 33 lean normoglycemic individuals.
O
Outcome
Serum concentrations of betatrophinsurrogate

Main Result

p-value: p=<.001

Serum betatrophin is decreased in human obesity and further reduced in obesity-associated insulin resistance, suggesting it may serve as a potential biomarker for cardiometabolic risk.

Cite This Study

Gómez‐Ambrosi et al. (2014) conducted a cross-sectional in Obesity and Type 2 Diabetes (n=153). Obesity and Type 2 Diabetes vs. Lean normoglycemic individuals was evaluated on Circulating concentrations of betatrophin (p=<.001). Obesity and type 2 diabetes were associated with significantly decreased circulating betatrophin levels compared to lean normoglycemic individuals (13.5 vs 45.1 ng/mL; P<0.001).

synapsesocial.com/papers/6a98705ba184c7fb06ada29ahttps://doi.org/10.1210/jc.2014-1568
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased circulating levels of betatrophin in individuals with long-standing type 1 diabetes2013 · 133 citations
  2. 2Elevated circulating lipasin/betatrophin in human type 2 diabetes and obesity2014 · 242 citations
  3. 3Elevated Mouse Hepatic Betatrophin Expression Does Not Increase Human β-Cell Replication in the Transplant Setting2013 · 118 citations
  4. 4Body Adiposity and Type 2 Diabetes: Increased Risk With a High Body Fat Percentage Even Having a Normal BMI2011 · 273 citations
  5. 5Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism2012 · 301 citations