Key result
Type 2 diabetes mellitus was associated with significantly higher circulating betatrophin levels compared to nondiabetic controls (SMD 0.53; 95% CI 0.13 to 0.94; P=0.010).
Why the study?
Are circulating betatrophin levels higher in patients with type 2 diabetes compared to nondiabetic adults?
Population
9 studies with 12 comparisons assessing T2DM patients and nondiabetic adults
Comparison
Type 2 diabetes mellitus (T2DM) vs Nondiabetic adults
Design
Meta-analysis
Authors
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Elevated betatrophin may mark T2DM risk; confirms association in meta-analysis but leaves open causality and utility.
Meta-Analysis
Are circulating betatrophin levels higher in patients with type 2 diabetes compared to nondiabetic adults?
Standardized Mean Difference: 0.53 (95% CI 0.13–0.94)
p-value: p=0.010
Circulating betatrophin levels are significantly elevated in nonobese patients with type 2 diabetes compared to nondiabetic controls, but this difference is not observed in obese individuals.
Li et al. (2015) conducted a meta-analysis in Type 2 diabetes mellitus. Type 2 diabetes mellitus vs. Nondiabetic adults was evaluated on Circulating betatrophin level (SMD 0.53, 95% CI 0.13 to 0.94, p=0.010). Type 2 diabetes mellitus was associated with significantly higher circulating betatrophin levels compared to nondiabetic controls (SMD 0.53; 95% CI 0.13 to 0.94; P=0.010).
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