Key result
Type 2 diabetes mellitus was associated with significantly higher serum betatrophin levels compared to normal controls (median 54.815 vs 11.250 ng/l; P<0.001).
Why the study?
Betatrophin is induced by insulin resistance and reported to modulate pancreatic beta-cell mass, but its role in type 2 diabetes mellitus required clinical evaluation.
Are serum betatrophin levels elevated in patients with type 2 diabetes mellitus compared to healthy controls?
Case-Control (n=80)
No
Are serum betatrophin levels elevated in patients with type 2 diabetes mellitus compared to healthy controls?
Absolute Event Rate: 54.815% vs 11.25%
p-value: p=<0.001
Serum betatrophin levels are significantly elevated in patients with type 2 diabetes mellitus, suggesting a potential role in its pathogenesis.
Higher betatrophin in T2DM supports biomarker research; hypothesis-generating and should not change practice.
Background: Type 2 DM is due primarily to lifestyle and genetic factors. A number of lifestyle factors are known to be important to the development of type 2 DM. Betatrophin, also known as angiopoietin-like protein (ANGPTL8), is a circulating protein predominantly produced in the liver and adipose tissue. Betatrophin is induced as a result of insulin resistance. It is reported to modulate pancreatic β-cell mass and glucose homeostasis reflectable on lipid metabolism. Aim of the Study: Evaluation of the role of betatrophin in patients with type 2 diabetes mellitus. Patients and Methods: This clinical study was carried out at Clinical Pathology Department, Tanta University Hospital and included 80 subjects who were divided into two groups: Group 1:40 Patients diagnosed with type 2 diabetes mellitus. Group 2: 40 normal subjects with matched age and sex as a control group. Results: In type 2 diabetes mellitus patients group, serum betatrophin ranged from 25.83 to 860.65 ng/l with a median value of 54.815 ng/l while in control group, betatrophin ranged from 7.5-53.2 ng/l with a madian value of 11.250 ng/l. There was significant statistical difference in betatrophin between the two groups. (P < 0.001). Betatrophin was significantly higher in type 2 diabtes mellitus patients as compared to control group. Conclusion: Circulating betatrophine concentrations were significantly increased in patients with T2 DM and associated with glucose homeostasis and insulin sensitivity. Thus, the level of serum betatrophin has a potential role in detection and pathogenesis of T2DM.
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El-Ghandour et al. (2019) conducted a case-control in Type 2 diabetes mellitus (n=80). Type 2 diabetes mellitus vs. Normal subjects was evaluated on Serum betatrophin level (p=<0.001). Type 2 diabetes mellitus was associated with significantly higher serum betatrophin levels compared to normal controls (median 54.815 vs 11.250 ng/l; P<0.001).
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