Key result
Plasma betatrophin levels correlate negatively with BMI, rising in anorexia and falling in morbid obesity.
Why the study?
How do circulating betatrophin levels vary across different body mass index categories in women?
Population
149 female patients, including 99 with extreme body mass index and 50 healthy eating/weight controls
Design
Cross-sectional
Authors
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Betatrophin-BMI associations in women are hypothesis-generating; prospective studies needed before clinical consideration.
Cross-Sectional (n=149)
How do circulating betatrophin levels vary across different body mass index categories in women?
Circulating betatrophin levels are regulated by metabolic status, being elevated in anorexia and decreased in morbid obesity.
Barja-Fernández et al. (2015) conducted a cross-sectional in Anorexia nervosa and obesity (n=149). Extreme body mass index (anorexia nervosa, obesity) vs. Healthy eating/weight controls was evaluated on Serum betatrophin levels. Plasma betatrophin levels were significantly elevated in anorexic patients and reduced in morbidly obese women compared with normal-weight controls, correlating negatively with weight and BMI.
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