Key result
A 12-week weight loss program restored the impaired betatrophin response during an oral glucose challenge in obese subjects, who had lower baseline fasting betatrophin than lean individuals (600.6 vs 759.5 pg/mL; P<0.05).
Why the study?
Does a 12-week weight-loss program restore glucose-driven betatrophin response in obese subjects?
Population
12 lean individuals and 20 obese subjects (n=32 humans), plus 3T3-L1 adipocytes for in vitro experiments.
Comparison
12-week structured weight-loss program and oral… vs Lean individuals and pre-weight loss state.
Design
Cohort
Follow-up
12 weeks
Authors
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Weight loss may restore betatrophin dynamics in obesity; hypothesis-generating and requires prospective validation before clinical consideration.
Cohort (n=32)
No
Does a 12-week weight-loss program restore glucose-driven betatrophin response in obese subjects?
p-value: p=<.001
Weight loss in obese individuals restores the impaired betatrophin response to glucose, suggesting a link between betatrophin and obesity-associated metabolic disturbances.
Maurer et al. (2016) conducted a cohort in Obesity (n=32). 12-week structured weight-loss program vs. Baseline (before weight loss) and lean individuals was evaluated on Circulating betatrophin levels during a glucose challenge (p=<.001). A 12-week weight loss program restored the impaired betatrophin response during an oral glucose challenge in obese subjects, who had lower baseline fasting betatrophin than lean individuals (600.6 vs 759.5 pg/mL; P<0.05).
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