August 19, 2015Cardiovascular DiabetologyOpen Access

Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects

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Population

749 subjects with Type 2 Diabetes (T2D) and non-diabetics

Design

Cross-sectional

Authors

MAMohamed Abu‐FarhaMubarak Al Kabeer Hospital JAJehad AbubakerDasman Diabetes Institute FNFiona NoronhaDasman Diabetes Institute

Discussion

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Implication

Betatrophin-C-peptide dissociation in T2D warrants caution against therapeutic targeting; leaves open diabetes-specific beta-cell regulation.

Structured PICO

Population

749 subjects with Type 2 Diabetes (T2D) and non-diabetics

Outcome

Association between plasma betatrophin level and C-peptidesurrogate

Increased betatrophin levels in T2D subjects do not correlate with increased C-peptide levels, suggesting it does not induce insulin production in this population.

Cite This Study

Abu‐Farha et al. (2015) studied this question.

synapsesocial.com/papers/6a80835ecf96de1eb9c88093 https://doi.org/10.1186/s12933-015-0277-1

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Implication

Betatrophin-C-peptide dissociation in T2D warrants caution against therapeutic targeting; leaves open diabetes-specific beta-cell regulation.

Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lack of associations between betatrophin/ANGPTL8 level and C-peptide in type 2 diabetic subjects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider