What does this research mean for the field?

A nilotinib-loaded liposomal gel significantly enhances the drug's dermal permeation, skin retention, and in vitro apoptotic activity against melanoma cells compared to free nilotinib. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study aims to develop a nilotinib-loaded liposomal gel for enhanced drug penetration and efficacy in melanoma treatment.

June 27, 2026ACS Applied Bio Materials

Quality by Design-Endorsed Nilotinib-Laden Liposomal Gel for Enhanced Dermal Delivery in Melanoma Management: Fabrication, Optimization, In Silico, In Vitro , and Ex Vivo Studies

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Authors

AHAachal Hedaoo PKPooja Khairnar GVGanesh Vambhurkar

Discussion

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Overview

Randomized trial demonstrates improved tumor cell inhibition in melanoma, suggesting a novel treatment approach.

Key Points

This study aims to develop a nilotinib-loaded liposomal gel for enhanced drug penetration and efficacy in melanoma treatment.
Fabricated nilotinib-loaded liposomes embedded in a Sepineo P600-based gel
Characterized particle size, PDI, zeta potential, drug loading, and entrapment efficiency
Conducted cytotoxicity and cellular uptake studies along with apoptosis assays
IC50 values for nilotinib were 12.5 μM and for NTB-loaded formulation were 6.25 μM, indicating enhanced potency
NTB-loaded liposomes increased early-stage apoptosis by 7.27-fold and late-stage apoptosis by 3.2-fold compared to free nilotinib
Ex vivo studies showed 3.1-fold improved permeation and 2.6-fold increased retention of nilotinib from the liposomal gel

Cite This Study

Hedaoo et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f462 https://doi.org/10.1021/acsabm.5c01778

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June 27, 2026ACS Applied Bio Materials

Quality by Design-Endorsed Nilotinib-Laden Liposomal Gel for Enhanced Dermal Delivery in Melanoma Management: Fabrication, Optimization, In Silico, In Vitro , and Ex Vivo Studies

View Full Paper

Ask AI

Bookmark

Authors

AHAachal Hedaoo PKPooja Khairnar GVGanesh Vambhurkar

Discussion

Member takes

Overview

Randomized trial demonstrates improved tumor cell inhibition in melanoma, suggesting a novel treatment approach.

Key Points

This study aims to develop a nilotinib-loaded liposomal gel for enhanced drug penetration and efficacy in melanoma treatment.
Fabricated nilotinib-loaded liposomes embedded in a Sepineo P600-based gel
Characterized particle size, PDI, zeta potential, drug loading, and entrapment efficiency
Conducted cytotoxicity and cellular uptake studies along with apoptosis assays
IC50 values for nilotinib were 12.5 μM and for NTB-loaded formulation were 6.25 μM, indicating enhanced potency
NTB-loaded liposomes increased early-stage apoptosis by 7.27-fold and late-stage apoptosis by 3.2-fold compared to free nilotinib
Ex vivo studies showed 3.1-fold improved permeation and 2.6-fold increased retention of nilotinib from the liposomal gel

Cite This Study

Hedaoo et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f462 https://doi.org/10.1021/acsabm.5c01778

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