Case-control study evaluates a new index for insulin resistance in obese children, suggesting its diagnostic value.
Key Points
This study aims to evaluate the effectiveness of the 20/(fasting C-peptide × fasting plasma glucose) index in detecting insulin resistance in obese children and adolescents.
Case-control design including 100 children (50 obese, 50 controls), ages 6–16 years.
Measured fasting blood glucose, serum insulin, C-peptide, and lipid profiles to assess insulin resistance using HOMA-IR and other metabolic indicators.
Statistical evaluations included comparisons of metabolic parameters and correlation analyses.
Obese children showed significantly elevated BMI and levels of fasting C-peptide and HOMA-IR compared to controls.
The 20/(Fcpep × FBG) index was lower in obese children (0.10 ± 0.04 vs. 0.18 ± 0.05, p < 0.001).
Sensitivity of 86.67% and specificity of 85% for predicting insulin resistance at a cut-off ≤0.164.