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June 27, 2026MetabolitesOpen Access

Urinary Albumin-to-Creatinine Ratio Across Phenotypes of Polycystic Ovary Syndrome: A Phenotype-Based Evaluation

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Authors

ÖÖÖznur ÖnerCACanan AkkuşDDDoga Demircioglu

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Overview

Cross-sectional study evaluates urinary albumin-to-creatinine ratio in PCOS phenotypes, suggesting metabolic burden doesn't equate to microvascular health implications.

Key Points

  • This study aims to evaluate urinary albumin-to-creatinine ratio across different phenotypes of polycystic ovary syndrome (PCOS) and its relation to metabolic parameters.
  • Cross-sectional study with 180 women aged 18-35 years with PCOS and 51 healthy controls.
  • PCOS phenotypes classified per Rotterdam criteria: A (n=96), B (n=19), C (n=35), D (n=30).
  • Insulin resistance was assessed via HOMA-IR and urinary albumin/creatinine levels were measured.
  • U-ACR was significantly elevated in Phenotype B compared to controls (p=0.018) and Phenotype D (p=0.016).
  • Phenotype A had a higher metabolic profile but no U-ACR elevation.
  • No significant correlation was found between U-ACR and age, BMI, or HOMA-IR.

Cite This Study

Öner et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6817aea7db3c1953f515https://doi.org/10.3390/metabo16070448
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Also Consider

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  1. 1Evaluation of C-reactive protein/albumin ratio in women with polycystic ovarian syndrome and women without polycystic ovarian syndrome2025
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  3. 3Polycystic Ovary Syndrome Accompanied by Hyperandrogenemia or Metabolic Syndrome Triggers Glomerular Podocyte Injury2024 · 1 citations
  4. 4Serum uric acid/creatinine ratio and free androgen index are synergistically associated with increased risk of polycystic ovary syndrome in obese women2022 · 22 citations
  5. 5TO ESTIMATE THE URIC ACID LEVELS IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME (PCOS)2024