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October 9, 2015Current Vascular Pharmacology

Lp-PLA2 levels were significantly higher in lean PCOS patients (mainly the 2 classic phenotypes) compared with lean controls, and in overweight/obese patients across all 4 phenotypes compared with overweight/obese controls, although evaluated CVD risk scores did not differ.

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Population

300 women, including 240 with Polycystic Ovary Syndrome according to the Rotterdam criteria and 60 controls…

Design

Cross-sectional

Authors

ΓΔΓεώργιος ΔασκαλόπουλοςAKArtemis KarkanakiAPAthanasia Piouka

Discussion

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Overview

Does not change CVD risk assessment in PCOS; leaves open Lp-PLA2 utility in classic phenotypes.

Structured PICO

P
Population
300 women, including 240 with Polycystic Ovary Syndrome (PCOS) according to the Rotterdam criteria and 60 controls without PCOS, subdivided by BMI (normal-weight and overweight/obese) and into 4 PCOS phenotypes.
C
Comparator
60 control women without PCOS, subdivided by BMI.
O
Outcome
Levels of surrogate markers of subclinical atherosclerosis (hsCRP and Lp-PLA2), levels of evaluated CVD risk score using risk engines, and several correlations of CVD risk factors.surrogate

Only the two classic Rotterdam phenotypes of PCOS exhibit excess cardiometabolic risk, suggesting that targeted treatment is needed to prevent CVD events in these specific subgroups.

Cite This Study

Δασκαλόπουλος et al. (2015) studied this question.

synapsesocial.com/papers/6a80e475adafcd383664699chttps://doi.org/10.2174/1567201812666150120163025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiovascular and Metabolic Risk Profiles Across Different Phenotypes of Polycystic Ovary Syndrome2025
  2. 2Body mass index outperforms the Rotterdam criteria in defining phenotypic heterogeneity in polycystic ovary syndrome: a multicenter study from the Italian PCOS registry (PCOSOUTCOME.net)2026
  3. 3Differences in clinical characteristics and cardiovascular disease risk prediction among Chinese women with polycystic ovary syndrome phenotypes: a cross-sectional study2026 · 1 citations
  4. 4Visceral Adiposity Index in Relation to Rotterdam Phenotypes of Polycystic Ovary Syndrome2025
  5. 5Polycystic Ovary Syndrome: Correlation between Phenotypes and Metabolic Syndrome2013 · 13 citations