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June 27, 2026Natural Product Research

Two new polyketides from the mangrove endophytic fungus Penicillium sp. FDZ-018-102

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Authors

ECEnkhchimeg ChuluunbaatarHainan Normal UniversityMWMei‐Zhu WuHainan Normal UniversityXSXin-Ming SongHainan Normal University

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Overview

Randomized trial evaluates antifungal and antibacterial compounds from Penicillium sp., suggesting potential therapies.

Key Points

  • This research aims to isolate and characterize new polyketides from a mangrove endophytic fungus and assess their biological activities.
  • Isolated two new polyketides, polyketiliums A and B, along with ten known compounds from Penicillium sp. FDZ-018-102.
  • Utilized spectroscopic methods to elucidate chemical structures and ECD calculations for absolute configuration determination.
  • Evaluated antifungal and antibacterial activities of the compounds against various strains.
  • Compound 11 exhibited notable antifungal activity against Fusarium oxysporum f. sp. cubense with an EC50 of 18.12 µg/mL, outperforming captan (EC50: 49.16 µg/mL).
  • Compound 11 showed equal MIC values of 32 μg/mL against Staphylococcus epidermidis and Bacillus cereus.
  • Compound 12 presented MIC values of 16 μg/mL against one strain and 32 μg/mL against another.

Cite This Study

Chuluunbaatar et al. (2026) studied this question.

synapsesocial.com/papers/6a3f6871aea7db3c1953f773https://doi.org/10.1080/14786419.2026.2691379
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Also Consider

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