What question did this study set out to answer?

This work aims to investigate the oxidative cyclization of bis(indol-2-ylmethyl)benzenesulfonamides to develop various heterocyclic frameworks.

PIDA/BF 3 ·OEt 2 -Mediated Cyclization of Bis(indoylmethyl)benzene Sulfonamides: Assembly of Di-indoloazepines, Spiro Carbolines, and Heterotriquinane Frameworks

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Randomized trial demonstrates oxidative cyclization outcomes in bis(indol-2-ylmethyl)benzenesulfonamides, indicating diverse heterocycle formations.

This work aims to investigate the oxidative cyclization of bis(indol-2-ylmethyl)benzenesulfonamides to develop various heterocyclic frameworks.
Utilized a metal-free hypervalent iodine-(III)-promoted oxidative cyclization approach.
Examined the effects of different isomeric bis(indol-2-ylmethyl)benzenesulfonamides.
Characterized the resulting heterocycles using single-crystal X-ray diffraction analyses.
Generated isomeric di-indoloazepines through mild oxidative cyclization.
Produced isomeric spiro β/γ-carbolines and bi-indole-2-carboxaldehydes through unexpected transformations.
Achieved formation of highly strained heterotriquinane frameworks from bis(indol-3-ylmethyl)benzenesulfonamides.

Harikrishnan et al. (2026) studied this question.

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Randomized trial demonstrates oxidative cyclization outcomes in bis(indol-2-ylmethyl)benzenesulfonamides, indicating diverse heterocycle formations.