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This study aims to explore the impact of Mecp2 loss on pubertal development and endocrine function in male mice.

Pubertal development and hypothalamic–pituitary–gonadal axis are altered in male mice lacking Mecp2

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Randomized trial assesses hormonal changes and puberty timing in male Mecp2 mutant mice, suggesting crucial roles in development.

This study aims to explore the impact of Mecp2 loss on pubertal development and endocrine function in male mice.
Used a mouse model with Mecp2 loss of function mutation to assess puberty onset and progression.
Measured circulating GnRH, LH, and testosterone in plasma samples and analyzed GnRH neurons in brain samples.
Evaluated weight gain and neurological symptoms in post-weaning mice until puberty.
Mecp2 CD1-null males exhibited delayed puberty with lower body weight at onset compared to wildtype controls.
These males had an increased number of GnRH neurons but lower circulating reproductive hormone levels.
Deficient testosterone-dependent arginine-vasopressin innervation was observed in Mecp2 CD1-null males.

Martín‐Sánchez et al. (2026) studied this question.

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