Randomized trial assesses epigenetic age acceleration in Hispanics versus Non-Hispanics, highlighting significant differences based on immigrant status.
Key Points
This research investigates how immigrant status, age at migration, and time since immigration influence epigenetic age acceleration (AA) by Hispanic ethnicity.
Analyzed data from 3918 participants in the Health and Retirement Study.
Compared epigenetic AA using regression models against chronological age employing Levine/PhenoAge, DunedinPoAm38, and GrimAge clocks.
Calculated immigration exposure contrasts for Hispanic and non-Hispanic groups.
Hispanic immigrants show slower epigenetic aging overall compared to non-Hispanic non-immigrants (ContrastGrimAge = -0.17, 95% CI: -0.32, -0.02).