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June 27, 2026FEBS Letters

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

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Authors

RRRonda J. Rolfes

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Overview

Review discusses phosphatases affecting inositol pyrophosphates, highlighting biochemical roles and implications in eukaryotes.

Key Points

  • This review aims to explore the roles of three families of phosphatases that act on inositol pyrophosphates and their collective influence on cellular functions.
  • Review literature on the three families of phosphatases: histidine acid, cysteine, and Nudix.
  • Discuss biochemical properties, distribution in eukaryotes, and impact on cellular processes across fungi, animals, and plants.
  • Identified overlapping substrate preferences among the three phosphatase families.
  • Discussed the biochemical characteristics of each phosphatase family, including enzyme structure and kinetic properties.
  • Highlighted the impact of phosphatases on PP-InsP pools and related cellular phenotypes.

Cite This Study

Ronda J. Rolfes (2026) studied this question.

synapsesocial.com/papers/6a3f694caea7db3c19540177https://doi.org/10.1002/1873-3468.70394
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