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June 27, 2026International Journal of Molecular SciencesOpen Access

Role of Supraspinal Neuroinflammation in Chronic Pain After Experimental Spinal Cord Injury—A Systematic Review

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Authors

TFTelma FerreiraCCCélia Duarte CruzJCJosé Tiago Costa‐Pereira

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Overview

Systematic review evaluates supraspinal neuroinflammation's link to chronic pain in animal models, suggesting further study is needed.

Key Points

  • This review aims to clarify the relationship between supraspinal neuroinflammation and chronic pain following spinal cord injury (SCI).
  • Systematic literature search conducted in PubMed, Web of Science, and Scopus.
  • Nine studies using rodent SCI models were analyzed, focusing on neuroinflammatory markers and pain-related behaviors.
  • Studies assessed microglial and astrocytic activation as well as pro-inflammatory cytokine levels.
  • Increased microglial and astrocytic activation linked to SCI was noted in various brain regions.
  • Reduction in neuroinflammation correlated with improvements in mechanical and thermal pain-related behaviors.
  • Significant methodological variation and risks of bias among studies limit the strength of conclusions.

Cite This Study

Ferreira et al. (2026) studied this question.

synapsesocial.com/papers/6a3f694caea7db3c19540259https://doi.org/10.3390/ijms27135711
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