What does this research mean for the field?

Neuropathic pain after spinal cord injury is associated with alterations in multiple large-scale brain networks, though current evidence is highly variable and insufficient to establish reproducible biomarkers or validated neuromodulation targets. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This review aims to summarize alterations in brain network connectivity associated with neuropathic pain following spinal cord injury.

June 6, 2026Neuroscience & Biobehavioral ReviewsOpen Access

Functional brain networks alterations in Neuropathic Pain After Spinal Cord Injury: A Systematic Review

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Authors

THTim HoThe University of Sydney JHJonas HolleThe University of Sydney KLKatleho LimakatsoUniversity of Cape Town

Discussion

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Implication

Systematic review shows altered brain networks in neuropathic pain after spinal cord injury, suggesting neuromodulation relevance.

Key Points

This review aims to summarize alterations in brain network connectivity associated with neuropathic pain following spinal cord injury.
Conducted a systematic review of resting-state functional MRI studies in SCI-NP.
Included original studies comparing SCI-NP participants with healthy controls or SCI without NP.
Extracted data on neuroimaging techniques, analysis methods, and connectivity findings.
Eight controlled studies involving 220 SCI-NP participants, 41 SCI without NP, and 152 healthy controls were reviewed.
Findings indicated recurring involvement of specific brain circuits like insular and thalamocortical regions.
No reproducible biomarker or validated neuromodulation target was established for SCI-NP.

Cite This Study

Ho et al. (2026) studied this question.

synapsesocial.com/papers/6a23b91b71a5da9775e751b0 https://doi.org/10.1016/j.neubiorev.2026.106794

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Functional brain networks alterations in Neuropathic Pain After Spinal Cord Injury: A Systematic Review

Discussion

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Implication

Key Points

Cite This Study

Functional brain networks alterations in Neuropathic Pain After Spinal Cord Injury: A Systematic Review

Discussion

Member takes

Implication

Key Points

Cite This Study

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