Key result
Neuropathic pain in spinal cord injury was associated with altered theta band connectivity in the fronto-parietal network and increased local efficiency compared to injury alone.
Why the study?
Neuropathic pain affects quality of life in almost 40% of spinal cord injury patients, and brain connectivity changes under different neuropathic pain conditions, motivating identification of networks altered by injury, pain, or both.
Does neuropathic pain and spinal cord injury alter brain functional connectivity during motor imagery?
Population
SCI patients with NP, SCI patients without NP, and able-bodied participants
Comparison
SCI patients with NP vs SCI patients without NP vs able-bodied participants
Design
Cohort study
Authors
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Hypothesis-generating for EEG connectivity biomarkers in SCI neuropathic pain; prospective validation required before clinical use.
Observational
Does neuropathic pain and spinal cord injury alter brain functional connectivity during motor imagery?
Neuropathic pain and spinal cord injury produce distinct alterations in brain functional connectivity during motor imagery, which may serve as diagnostic biomarkers.
Hasan et al. (2021) conducted an observational in Spinal cord injury and neuropathic pain. Neuropathic pain following spinal cord injury vs. Spinal cord injury without neuropathic pain and able-bodied controls was evaluated on Brain functional connectivity measured by EEG phase locked value, cluster coefficient, and local efficiency. Neuropathic pain in spinal cord injury was associated with altered theta band connectivity in the fronto-parietal network and increased local efficiency compared to injury alone.
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