What question did this study set out to answer?

The aim is to understand the coexistence of PRDM9-guided and non-PRDM9-guided recombination hotspots and their evolutionary implications.

On the origin of PRDM9-guided recombination hotspots

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Randomized trial investigates the dynamics of PRDM9-guided recombination hotspots, suggesting evolutionary trade-offs in vertebrates.

The aim is to understand the coexistence of PRDM9-guided and non-PRDM9-guided recombination hotspots and their evolutionary implications.
Developed a population genetic model to analyze competitive dynamics of hotspot types.
Considered crossovers required for chromosome segregation and binding specificity of recombination hotspots.
Non-PRDM9-guided hotspots generally favor more crossovers for chromosome segregation.
PRDM9 can enhance binding probability in certain scenarios, favoring symmetric binding among homologous chromosomes.
Intermediate selection regimes allow stable coexistence of PRDM9 and non-PRDM9 hotspots.

Úbeda et al. (2026) studied this question.

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