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June 27, 2026Annals of Surgery

Efficacy of Splenectomy for Hematologic Malignancies

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Authors

HMHamza MohammedCity Of Hope National Medical CenterMWMuhammad Talha WaheedCity of HopeVTVijay TrisalCity Of Hope National Medical Center

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Overview

Retrospective study evaluates splenectomy outcomes in hematologic malignancies, suggesting variable success rates.

Key Points

  • This study aims to evaluate the indications and outcomes of splenectomy in patients with hematologic malignancies.
  • Retrospective study of patients who underwent splenectomy at an NCI-designated center from 2009 to 2024.
  • Patients were categorized by indication: lymphoid, myeloid, and a small subgroup with benign conditions.
  • Primary outcome measured was postoperative complication rate (30 days) and secondary outcome was splenectomy success based on indications.
  • 79 patients included: 37 lymphoid, 33 myeloid, 5 immune thrombocytopenic purpura, and 4 others.
  • The overall 30-day complication rate was 49%; 22% experienced grade 3 or higher complications.
  • Success rates varied: 91.7% for bridge-to-transplant; lower for achieving transfusion independence in cytopenia.

Cite This Study

Mohammed et al. (2026) studied this question.

synapsesocial.com/papers/6a3f69caaea7db3c19540847https://doi.org/10.1097/sla.0000000000007139
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes of splenectomy in benign and malignant hematologic conditions in the immunotherapy era2025
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  5. 5Splenomegaly and Response to Splenectomy in Immune Thrombocytopenia2024 · 2 citations