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June 27, 2026Current OncologyOpen Access

Effectiveness of Nurse-Led Digital Health Interventions on Symptom Management and Quality of Life in Cancer Patients Undergoing Systemic Therapy: A Systematic Review of Randomized Controlled Trials

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Systematic review evaluates nurse-led digital interventions for symptom management in cancer patients, suggesting significant benefits.

This review aims to evaluate the effectiveness of nurse-led digital health interventions on symptom management and quality of life in cancer patients undergoing systemic therapy.
Conducted a systematic review following PRISMA 2020 guidelines across four databases from inception to January 2025.
Included only randomized controlled trials (RCTs) with adults undergoing anticancer therapy evaluating digital health interventions.
Assessed risk of bias; included nine RCTs with a total of 3344 participants.
Nurse-led interventions using digital tools reduced symptom burden by approximately 43% (e.g., Symptom Care at Home system).
Interventions improved health-related quality of life outcomes and reduced anxiety and severe toxicities.
Combined automated monitoring and structured follow-up showed the greatest benefits.

Alqaisi et al. (2026) studied this question.

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