What does this research mean for the field?

Posterior mitral leaflet extension using fresh autologous pericardium is a viable surgical option for pediatric mitral regurgitation with posterior leaflet shortening, resulting in no mortality and low reintervention rates over mid-term follow-up. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 27, 2026General Thoracic and Cardiovascular Surgery

Mid-term outcomes of posterior mitral leaflet extension using fresh autologous pericardium for pediatric mitral regurgitation

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Pediatric mitral regurgitation (n=6). Intervention: Posterior mitral leaflet extension using fresh autologous pericardium. Primary outcome: Mortality and mitral valve reintervention.

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Key result

Posterior mitral leaflet extension using autologous pericardium shows ~17% long-term reintervention risk in children.

Why the study?

Achieving sufficient leaflet coaptation can be difficult in pediatric mitral regurgitation with posterior leaflet shortening or tethering, and reports on posterior leaflet extension using autologous pericardium in pediatric patients remain limited.

Does posterior mitral leaflet extension using fresh autologous pericardium improve outcomes and prevent reintervention in pediatric patients with mitral regurgitation?

Population

6 pediatric patients undergoing posterior mitral leaflet extension for MR

Comparison

Posterior mitral leaflet extension using fresh autologous pericardium

Design

Retrospective review

Follow-up

Median 10.6 (1.7–14.2) years

Authors

RKRyoichi KondoKitasato University KMKagami MiyajiKitasato University HKHideki KonakaKitasato University

Discussion

Member takes

Implication

Hypothesis-generating for pericardial extension in pediatric MR; larger prospective studies needed before adoption.

Key Points

This study aims to evaluate the mid-term outcomes of posterior mitral leaflet extension using fresh autologous pericardium in pediatric mitral regurgitation.
Retrospective review of six pediatric patients undergoing posterior mitral leaflet extension using fresh autologous pericardium for mitral regurgitation.
All patients received annuloplasty, with a median follow-up of 10.6 years (1.7–14.2).
Serial echocardiography assessed mitral regurgitation severity and valve function.
There were no operative or late deaths during the follow-up period.
One patient required mitral valve replacement due to recurrent mitral regurgitation 3 months post-surgery.
In the remaining patients, mitral regurgitation was mild or less at the last follow-up.

Study Design

Type

Observational (n=6)

Structured PICO

Does posterior mitral leaflet extension using fresh autologous pericardium improve outcomes and prevent reintervention in pediatric patients with mitral regurgitation?

Population

6 pediatric patients (median age 1.5 years) with mitral regurgitation associated with posterior leaflet shortening, followed for a median of 10.6 years.

Exposure

Posterior mitral leaflet extension using fresh autologous pericardium, with annuloplasty performed in all patients.

Outcome

Mortality and mitral valve reinterventionhard clinical

Posterior mitral leaflet extension using fresh autologous pericardium is a viable surgical option with favorable mid-term durability for pediatric patients with mitral regurgitation.

Cite This Study

Kondo et al. (2026) conducted an observational in Pediatric mitral regurgitation (n=6). Posterior mitral leaflet extension using fresh autologous pericardium was evaluated on Mortality and mitral valve reintervention. Posterior mitral leaflet extension using fresh autologous pericardium in pediatric patients resulted in no deaths and one mitral valve reintervention (16.7%) over a median follow-up of 10.6 years.

synapsesocial.com/papers/6a3f6bb8aea7db3c19540a93 https://doi.org/10.1007/s11748-026-02340-5

Topics

Mitral valve intervention

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Mid-term outcomes of posterior mitral leaflet extension using fresh autologous pericardium for pediatric mitral regurgitation

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

Mid-term outcomes of posterior mitral leaflet extension using fresh autologous pericardium for pediatric mitral regurgitation

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

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