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July 1, 1996Journal of Cell Science

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn

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Authors

LCLeslie A. CaryCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaJCJ ChangCornell UniversityJGJun‐Lin GuanThe Ohio State University Wexner Medical Center

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Implication

Randomized trial reveals that overexpressing focal adhesion kinase boosts cell migration, indicating its role in integrin signaling.

Key Points

  • The aim is to investigate how overexpression of focal adhesion kinase (FAK) affects cell migration and its interaction with Src and Fyn.
  • CHO cells were used to study the effects of FAK overexpression on migration on fibronectin.
  • Mutations were introduced in FAK to assess the role of specific phosphorylation sites.
  • Associations between wild-type, kinase-defective FAK, and Src/Fyn were evaluated.
  • FAK overexpression increased CHO cell migration on fibronectin.
  • The FAK Y397 mutation abolished the stimulation of migration.
  • The wild-type and kinase-defective FAK associated with Src and Fyn, while the F397 mutant did not.

Cite This Study

Cary et al. (1996) studied this question.

synapsesocial.com/papers/6a3f74eb4a2d33c351cd33b3https://doi.org/10.1242/jcs.109.7.1787
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