Key result
High adipose tissue insulin resistance is linked to ~2.4-fold higher odds of aortic valve calcification.
Why the study?
Is adipose tissue or hepatic insulin resistance associated with coronary artery or aortic valve calcification in subjects without history of coronary heart disease?
Cross-Sectional (n=1,201)
No
Is adipose tissue or hepatic insulin resistance associated with coronary artery or aortic valve calcification in subjects without history of coronary heart disease?
Adipose tissue insulin resistance is independently associated with the presence of aortic valve calcification, suggesting abnormal adipose tissue function may promote its development.
No clinical action warranted for aortic valve calcification; extends metabolic associations but leaves causal role open.
Background . Insulin resistance is involved in the pathogenesis of cardiovascular disease, but its relationship with cardiovascular calcification has yielded conflicting results. The purpose of the present study was to investigate the role of hepatic and adipose tissue insulin resistance on the presence of coronary artery (CAC > 0) and aortic valve calcification (AVC > 0). Methods . In 1201 subjects (52% women,53.6±9.3years old) without familiar and personal history of coronary heart disease, CAC and AVC were assessed by multidetector-computed tomography. Cardiovascular risk factors were documented and lipid profile, inflammation markers, glucose, insulin, and free fatty acids were measured. Hepatic insulin resistance (HOMA-IR) and adipose tissue insulin resistance (Adipo-IR) indices were calculated. Results . There was a significant relationship between HOMA-IR and Adipo-IR indices (r=0.758,p<0.001). Participants in the highest quartiles of HOMA-IR and Adipo-IR indices had a more adverse cardiovascular profile and higher prevalence of CAC > 0 and AVC > 0. After full adjustment, subjects in the highest quartile of Adipo-IR index had higher odds of AVC > 0 (OR: 2.40; 95% CI: 1.30–4.43), as compared to those in the lowest quartile. Conclusions . Adipo-IR was independently associated with AVC > 0. This suggests that abnormal adipose tissue function favors insulin resistance that may promote the development and progression of AVC.
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Jorge‐Galarza et al. (2016) conducted a cross-sectional in Subclinical cardiovascular calcification (n=1,201). Adipose tissue insulin resistance (Adipo-IR) vs. Lowest quartile of Adipo-IR was evaluated on Presence of aortic valve calcification (AVC > 0) (OR 2.40, 95% CI 1.30-4.43). Subjects in the highest quartile of adipose tissue insulin resistance had 2.4 times higher odds of having aortic valve calcification compared to those in the lowest quartile.
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