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July 1, 2007Journal of EndocrinologyOpen Access

Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse

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Key result

Myostatin overexpression in mice reduced left ventricular mass by 21% but did not affect cardiac systolic function compared to wild-type controls.

Why the study?

Does myostatin overexpression or blockade alter left ventricular mass and ejection fraction in mice?

Population

7-week-old male transgenic mice overexpressing myostatin, myostatin knockout mice, wild-type controls, and…

Comparison

Genetic overexpression of myostatin, genetic… vs Wild-type mice of respective strains and…

Design

Preclinical

Follow-up

7 weeks of age

Authors

JAJorge N. ArtazaCharles R. Drew University of Medicine and ScienceSRSuzanne Reisz‐PorszaszCharles R. Drew University of Medicine and ScienceJDJoan DowCity Of Hope National Medical Center

Discussion

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Implication

May reduce LV mass without systolic harm in mice; extends myostatin biology but leaves human therapeutic translation open.

Structured PICO

Does myostatin overexpression or blockade alter left ventricular mass and ejection fraction in mice?

P
Population
7-week-old male transgenic mice overexpressing myostatin and myostatin knockout mice compared to wild-type controls to assess cardiac mass and function.
I
Intervention
Genetic overexpression of myostatin (Mst TG), genetic blockade of myostatin (Mst -/-), and in vitro treatment with recombinant myostatin or anti-myostatin antibody.
C
Comparator
Wild-type mice of respective strains and untreated/vehicle-treated cardiomyocytes.
O
Outcome
Left ventricular mass, heart weight, left ventricular ejection fraction (LVEF), and in vitro cardiomyocyte proliferation.surrogate

Myostatin negatively regulates cardiac mass and cardiomyocyte proliferation without affecting left ventricular systolic function in mice.

Limitations

  • Animals were only 7 weeks old, so long-term effects in aged animals are unknown
  • No morphometric histological analysis of the heart was performed

Cite This Study

Artaza et al. (2007) studied Cardiac left ventricular mass and function. Myostatin overexpression or knockout vs. Wild-type mice was evaluated on Left ventricular ejection fraction and cardiac mass. Myostatin overexpression in mice reduced left ventricular mass by 21% but did not affect cardiac systolic function compared to wild-type controls.

synapsesocial.com/papers/6a3f7eb42701f9edca08ee96https://doi.org/10.1677/joe-07-0072
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Also Consider

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