Lipoprotein Remnants and Endothelial Dysfunction in the Postprandial Phase
Key result
An oral fat load significantly decreased flow-mediated dilatation at 6 hours (from 16.03% to 11.53%, P<0.01), which correlated with postprandial cholesterol in remnant lipoproteins (R=0.63, P=0.012).
Why the study?
Does an oral fat load alter endothelial function in moderately dyslipidemic men?
Population
15 moderately dyslipidemic men
Comparison
Oral fat load (OFL) vs Baseline (fasting state before OFL ingestion)
Design
Cohort
Follow-up
8 hours
Authors
Discussion
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Implication
Postprandial RLP changes may associate with endothelial dysfunction; hypothesis-generating in small observational data and requires prospective confirmation.
Structured PICO
Does an oral fat load alter endothelial function in moderately dyslipidemic men?
P
Population
15 moderately dyslipidemic men evaluated for endothelial function up to 8 hours after an oral fat load.
I
Intervention
Oral fat load (OFL)
C
Comparator
Baseline (fasting state before OFL ingestion)
O
Outcome
Endothelial function, determined as flow-mediated dilatation (FMD) of the brachial arterysurrogate
Main Result
Absolute Event Rate: 11.53% vs 16.03%
p-value: p=<0.01
Postprandial increases in remnant lipoprotein cholesterol are significantly associated with transient endothelial dysfunction in dyslipidemic men.
Cite This Study
Maggi et al. (2004) studied Moderate dyslipidemia (n=15). Oral fat load vs. Baseline was evaluated on Flow-mediated dilatation (FMD) of the brachial artery at 6 hours (p=<0.01). An oral fat load significantly decreased flow-mediated dilatation at 6 hours (from 16.03% to 11.53%, P<0.01), which correlated with postprandial cholesterol in remnant lipoproteins (R=0.63, P=0.012).