Key result
Following a fat loading test, the postprandial remnant-like particle positive rate was significantly higher in normolipidemic patients with coronary artery disease compared to healthy controls (93% vs 20%, p<0.001).
Why the study?
Does a fat loading test reveal impaired postprandial lipemia and accumulation of remnant-like particles in normolipidemic patients with coronary artery disease compared to healthy controls?
Population
30 normolipidemic males: 15 angiographically defined patients with coronary artery disease and 15 healthy…
Comparison
Fat loading test. vs Healthy normolipidemic controls receiving the…
Design
Case-control
Follow-up
12 hours
Authors
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Supports postprandial remnant assessment in normolipidemic CAD; leaves open causal and therapeutic implications.
Case-Control (n=30)
Does a fat loading test reveal impaired postprandial lipemia and accumulation of remnant-like particles in normolipidemic patients with coronary artery disease compared to healthy controls?
Absolute Event Rate: 93% vs 20%
p-value: p=<0.001
Even in the absence of fasting hyperlipidemia, patients with coronary artery disease exhibit significant postprandial accumulation of atherogenic remnant-like particles, highlighting postprandial lipemia as a key risk factor.
Katsunori Ikewaki (1990) conducted a case-control in Coronary Artery Disease (n=30). Coronary artery disease vs. Healthy controls was evaluated on Postprandial remnant-like particle (RLP) positive rate (p=<0.001). Following a fat loading test, the postprandial remnant-like particle positive rate was significantly higher in normolipidemic patients with coronary artery disease compared to healthy controls (93% vs 20%, p<0.001).
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