Key result
Anti-GM1 IgM antibodies were detected in 23% of patients with motor neuron disease and 19% of patients with neuropathy, compared to 7% of controls.
Why the study?
Is the frequency of anti-GM1 IgM antibodies higher in patients with motor neuron disease and neuropathy compared to controls?
Population
232 patients, comprising 56 with motor neuron disease, 69 with neuropathy, and 107 controls with other…
Design
Case-control
Authors
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Should not yet change management; leaves open pathogenic role and need for prospective validation.
Case-Control (n=232)
Is the frequency of anti-GM1 IgM antibodies higher in patients with motor neuron disease and neuropathy compared to controls?
Absolute Event Rate: 23% vs 7%
Anti-GM1 IgM antibodies are more frequently found in patients with motor neuron disease and neuropathy compared to controls, though their pathogenic role remains unclear.
Nobile‐Orazio et al. (1990) conducted a case-control in Motor neuron disease and neuropathy (n=232). Motor neuron disease and neuropathy vs. Controls with other neurologic and nonneurologic diseases was evaluated on Presence of anti-GM1 IgM antibodies. Anti-GM1 IgM antibodies were detected in 23% of patients with motor neuron disease and 19% of patients with neuropathy, compared to 7% of controls.
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