Key result
Metabolic syndrome linked to ~156% higher risk of subclinical hypothyroidism, unlike its individual components.
Why the study?
Subclinical hypothyroidism is linked to clinical hypothyroidism and ischemic heart disease, but its relationship with metabolic syndrome needed evaluation.
Does metabolic syndrome increase the risk of subclinical hypothyroidism?
Meta-Analysis (n=73,576)
Does metabolic syndrome increase the risk of subclinical hypothyroidism?
Odds Ratio: 2.56 (95% CI 1.44–4.55)
Metabolic syndrome is associated with a significantly increased risk of subclinical hypothyroidism, highlighting the need for thyroid function screening in this population.
Background: Subclinical hypothyroidism (SCH) is a common endocrine subclinical disorder, the main adverse consequences of which are the development of clinical hypothyroidism and the promotion of ischemic heart disease. Metabolic syndrome (MetS) is a collection of metabolic problems. The goal of this meta-analysis was to evaluate the relationship between MetS and SCH. Methods: Suitable publications were identified using PubMed, Embase, and the Cochrane Library. The meta-analysis included only studies in English that reported odds ratio (OR) data for MetS and SCH. Two researchers combined data using a random-effects model. OR and 95% confidence intervals (CIs) were used to present the results. Results: MetS was associated with an elevated risk of developing SCH (OR 2.56, 95% CI 1.44-4.55). However, the individual components of MetS were not associated with the risk of SCH. Subgroup analysis revealed that different definitions of MetS had varying effects on SCH. Sensitivity analysis confirmed that our results were robust. Conclusions: This meta-analysis indicates that patients with MetS have an increased risk of SCH, while there is no significant association between the five individual components of MetS and the risk of SCH. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023454415.
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Zhong et al. (2024) conducted a meta-analysis in Metabolic syndrome and subclinical hypothyroidism (n=73,576). Metabolic syndrome vs. Without metabolic syndrome was evaluated on Risk of developing subclinical hypothyroidism (OR 2.56, 95% CI 1.44-4.55). Metabolic syndrome was associated with a significantly elevated risk of developing subclinical hypothyroidism (OR 2.56), although its individual components were not independently associated.
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