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Ultrasound-responsive nanomaterials represent a cutting-edge approach to cancer immunotherapy. Their emergence has unlocked novel capabilities in targeted drug delivery and immune modulation, offering unparalleled advantages for optimizing treatment outcomes. This review primarily discusses the application potential of ultrasound-responsive nanosystems in antitumor immunity, highlighting their ability to accelerate immunogenic cell death (ICD) and modulate the tumor microenvironment (TME). These nanocarriers exhibit remarkable efficacy in transporting therapeutic agents directly to tumor sites under ultrasound guidance, thereby increasing the specificity and efficacy of treatment. Additionally, this review explores the unique biological stability and drug delivery capabilities of ultrasound-responsive nanomaterials, which are essential for their clinical application. In the context of immune imaging, these nanomaterials can potentially monitor therapeutic responses in real time, offering a visual understanding of treatment effectiveness and patient prognosis. Ultimately, fully realizing the translational potential of ultrasound-responsive nanomaterials in anticancer immunity will help pave the way for personalized and effective cancer management.
Wang et al. (Tue,) studied this question.