Complete excision of a rare pediatric angiomatoid fibrous histiocytoma in a 6-year-old child resulted in the patient remaining disease-free.
Case Report (n=1)
No
Comprehensive clinical, histological, immunohistochemical, and molecular analysis is crucial for accurately diagnosing angiomatoid fibrous histiocytoma and avoiding misdiagnosis.
Abstract Angiomatoid fibrous histiocytoma (AFH) is a rare pediatric soft-tissue tumor of intermediate malignancy, often misdiagnosed because of its resemblance to benign and malignant lesions. We report a 6-year-old child with a slowly enlarging subcutaneous nodule on the right forearm. Initial biopsy showed small, round cells positive for cluster differentiation 99. Complete excision revealed a circumscribed mesenchymal tumor with angiomatoid cavities and fibrous pseudocapsule. Immunohistochemistry and molecular studies confirmed AFH and excluded Ewing sarcoma. The patient remains disease-free after complete excision; prognosis is generally favorable with surgical management and long-term follow-up. This case highlights the diagnostic challenge of AFH and the importance of a comprehensive clinical, histological, immunohistochemical, and molecular analysis to avoid misdiagnosis.
García‐Verdú et al. (Wed,) conducted a case report in Angiomatoid fibrous histiocytoma (n=1). Complete excision was evaluated on Disease status. Complete excision of a rare pediatric angiomatoid fibrous histiocytoma in a 6-year-old child resulted in the patient remaining disease-free.
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