Percutaneous transluminal coronary angioplasty significantly increased plasma BNP to a peak concentration of 66.1 pg/ml at 24 hours, whereas diagnostic coronary angiography did not.
Observational (n=79)
Does transient myocardial ischemia induced by PTCA increase plasma BNP concentrations in patients undergoing coronary procedures?
Transient myocardial ischemia induced by PTCA balloon inflation causes a significant, transient increase in plasma BNP levels at 24 hours.
Absolute Event Rate: 66.1% vs 33.7%
BACKGROUND: Brain (B-type) natriuretic peptide (BNP) is known to be secreted predominantly from the myocardium. Brain natriuretic peptide plasma concentrations have been shown to be markedly increased in patients with acute myocardial infarction; however, plasma BNP response during episodes of myocardial ischemia has not been established. HYPOTHESIS: This study was designed to examine plasma BNP in patients with transient myocardial ischemia induced by inflation of a percutaneous transluminal coronary angioplasty (PTCA) balloon. METHODS: Thirty consecutive patients (26 men and 4 women; mean age 61 years) who underwent PTCA, and another 49 patients (39 men and 10 women; mean age 63 years) who underwent diagnostic coronary angiography were enrolled in this study. Serum BNP concentrations were assayed in all patients. RESULTS: Plasma BNP was increased significantly with a peak concentration of 66.1 +/- 65.2 pg/ml 24 h after PTCA. Coronary angiography did not cause plasma BNP increase (immediately before 30.4 +/- 29.0 pg/ml, 24 h after 33.7 +/- 30.6 pg/ml). No significant differences were present in hemodynamic parameters measured immediately before and 24 h after PTCA. CONCLUSION: Plasma BNP is increased by transient myocardial ischemia induced by PTCA.
Tateishi et al. (Sun,) conducted a observational in Transient myocardial ischemia (n=79). Percutaneous transluminal coronary angioplasty (PTCA) vs. Diagnostic coronary angiography was evaluated on Plasma BNP concentration at 24 hours. Percutaneous transluminal coronary angioplasty significantly increased plasma BNP to a peak concentration of 66.1 pg/ml at 24 hours, whereas diagnostic coronary angiography did not.