Key result
Epstein-Barr virus genome was detected in the myocytes of 6.3% of patients with inflammatory cardiomyopathy, who experienced progressive cardiac dysfunction despite conventional therapy.
Why the study?
Can laser capture microdissection detect Epstein-Barr virus genome specifically in myocytes of patients with inflammatory cardiomyopathy?
Population
142 patients with cardiac dilation and dysfunction and a histological and immunohistochemical diagnosis of…
Comparison
Laser capture microdissection and polymerase… vs Blood and myocardial samples from patients with…
Design
Cohort
Follow-up
mean 31+/-14 months
Authors
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Supports direct EBV myocardial infection in inflammatory cardiomyopathy; leaves open antiviral therapy benefit pending prospective trials.
Observational (n=142)
Can laser capture microdissection detect Epstein-Barr virus genome specifically in myocytes of patients with inflammatory cardiomyopathy?
Detection of EBV genome specifically within myocytes supports a direct cytopathic role for EBV in inflammatory cardiomyopathy.
Chimenti et al. (2004) conducted an observational in Inflammatory cardiomyopathy (n=142). Epstein-Barr virus (EBV) myocardial infection vs. Controls with positive and negative serology for EBV was evaluated on Intramyocyte detection of EBV genome. Epstein-Barr virus genome was detected in the myocytes of 6.3% of patients with inflammatory cardiomyopathy, who experienced progressive cardiac dysfunction despite conventional therapy.
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