The inner centromere protein (INCENP) antigens: movement from inner centromere to midbody during mitosis.
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Implication
Novel polypeptide antigens show dynamic localization changes during mitosis, implying roles in cell division processes.
Key Points
- This research aims to explore the localization and function of INCENP antigens during mitosis.
- Identified INCENPs using monoclonal antibodies against mitotic chromosome scaffold proteins.
- Analyzed structural localization changes of INCENPs during metaphase, anaphase, and telophase using microscopy.
- INCENPs localize between sister chromatids in metaphase, fully dissociating during anaphase (100% scaffold association).
- During anaphase, INCENPs are found in the central spindle and near the cell membrane, eventually focusing on the midbody during telophase.
Cite This Study
Cooke et al. (1987) studied this question.