Key result
Lowest haemoglobin quintile linked to ~4-fold higher all-cause mortality in men undergoing elective PCI.
Why the study?
Does baseline haemoglobin concentration affect long-term mortality in male patients undergoing elective PCI?
Cohort (n=689)
No
Does baseline haemoglobin concentration affect long-term mortality in male patients undergoing elective PCI?
Baseline anaemia is associated with a markedly increased risk of long-term mortality in male patients undergoing elective PCI.
Answers are grounded in this paper and cite their sources.
Anaemia associated with higher post-PCI mortality; hypothesis-generating for correction trials before practice change.
AIMS: It has recently been proposed that anaemia is an independent risk factor for development of cardiovascular disease in the general population. The impact of anaemia on long-term survival of patients with manifest coronary heart disease (CHD) has not been assessed so far. In this study, we examined the influence of haemoglobin concentrations on the outcome after percutaneous coronary interventions (PCI). METHODS AND RESULTS: In a retrospective cohort study, we analysed in-hospital and long-term mortality in all male patients admitted to our institution for elective PCI from 1998 to 1999. In 689 cases, complete follow-up information could be obtained (98.4%). Depending on their baseline haemoglobin, patients were divided in quintiles. In all subgroups, angiographic success after PCI (90-94%) was comparably high and in-hospital mortality was low (0-0.7%). During follow-up (median 697 days), patients in the lowest haemoglobin quintile (</=12.9g/dl) were significantly more likely to suffer from all-cause death (22.2%) than those of the other quintiles (3.7-12.1%; estimated mortality rates from Kaplan-Meier models, P<0.0001, log rank test). In more detail, we found a U-shaped relationship between mortality and haemoglobin strata in steps of 1g/dl (P<0.0001, log rank test). After adjustment for potential co-variates, patients of the lowest haemoglobin quintile showed in Cox regression analysis a markedly higher risk for death (adjusted hazard rate ratio (HRR) 4.09, 95% confidence interval (CI) 1.52-11.05) compared to the quintile with a haemoglobin concentration of 14.6-15.2g/dl. CONCLUSIONS: These results indicate that anaemia is associated with markedly reduced survival in patients with CHD after elective PCI. Since PCI is a common intervention and anaemia is a frequent condition in the general population, strategies for the management of anaemic PCI patients and treatment of anaemic patients with CHD should be developed.
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Holger Reinecke (2003) conducted a cohort in Coronary heart disease (CHD) undergoing elective PCI (n=689). Lowest haemoglobin quintile (≤12.9 g/dl) vs. Haemoglobin concentration of 14.6-15.2 g/dl was evaluated on All-cause death (HR 4.09, 95% CI 1.52-11.05, p=<0.0001). In male patients undergoing elective PCI, the lowest haemoglobin quintile (≤12.9 g/dl) was associated with a significantly higher risk of all-cause death (adjusted HR 4.09; 95% CI 1.52-11.05).
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