Key result
A high burden of premature ventricular contractions (>25 beats) during exercise was associated with an increased risk of major adverse cardiovascular events (HR 1.8) in asymptomatic individuals.
Why the study?
The clinical consequences of exercise-induced premature ventricular contractions in asymptomatic individuals remained unclear.
Does a higher burden of premature ventricular contractions during exercise and recovery increase the risk of MACE and mortality in asymptomatic individuals?
Population
48,502 asymptomatic participants from UK Biobank
Comparison
Different PVC burdens during exercise and recovery stress testing
Design
Cohort study
Follow-up
Median 11.5 years
Authors
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May inform risk stratification via exercise ECGs in asymptomatic adults; leaves open whether PVC-targeted interventions improve outcomes.
Cohort (n=48,502)
Yes
Does a higher burden of premature ventricular contractions during exercise and recovery increase the risk of MACE and mortality in asymptomatic individuals?
Hazard Ratio: 1.8 (95% CI 1.4–2.3)
Absolute Event Rate: 9.4% vs 3.6%
p-value: p=<0.001
Even low burdens of exercise-induced PVCs in asymptomatic individuals are independently associated with an increased risk of MACE and mortality, demonstrating a dose-response relationship.
Duijvenboden et al. (2023) conducted a cohort in Asymptomatic individuals without known cardiovascular disease (n=48,502). Premature ventricular contractions (PVCs) during exercise (>25 PVCs) vs. No PVCs (0 PVCs) was evaluated on Major adverse cardiovascular events (MACE; hospitalisation or death due to myocardial infarction, heart failure, or life-threatening ventricular arrhythmia) (HR 1.8, 95% CI 1.4-2.3, p=<0.001). A high burden of premature ventricular contractions (>25 beats) during exercise was associated with an increased risk of major adverse cardiovascular events (HR 1.8) in asymptomatic individuals.
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