Key result
Trimipramine and doxepin were equally effective for depression and anxiety, with minimal cardiovascular effects (premature contractions in 3 trimipramine and 5 doxepin patients).
Why the study?
Does trimipramine compared to doxepin improve cardiac safety and therapeutic efficacy in young-elderly patients with Major Depressive Episode?
Population
37 young-elderly patients with a diagnosis of Major Depressive Episode treated at a psychiatric out-patient…
Comparison
Trimipramine titrated over 2 weeks in the dosage… vs Doxepin titrated over 2 weeks in the dosage…
Design
RCT, Randomized parallel group, 1-week single-blind placebo period followed by…
Follow-up
5 weeks
Authors
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Supports either agent for young-elderly depression with cardiac concerns; extends RCT evidence on TCA safety profiles.
RCT (n=37)
Double-blind
parallel group
No
Does trimipramine compared to doxepin improve cardiac safety and therapeutic efficacy in young-elderly patients with Major Depressive Episode?
Trimipramine and doxepin demonstrate comparable and minimal cardiovascular effects alongside equal antidepressant efficacy in young-elderly patients.
Nair et al. (1993) conducted an RCT in Major Depressive Episode (n=37). Trimipramine vs. Doxepin was evaluated on Psychiatric effects (Hamilton Rating Scale for Depression, Hamilton Anxiety Rating Scale, Clinical Global Impression Scale) and cardiovascular effects. Trimipramine and doxepin were equally effective for depression and anxiety, with minimal cardiovascular effects (premature contractions in 3 trimipramine and 5 doxepin patients).
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