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This study aims to explore the impact of curcumin supplementation on oxidative stress and exercise performance in Wistar rats.

Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model

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Randomized trial investigates curcumin's role in reducing muscle damage and improving exercise performance in rats, suggesting dietary interventions.

This study aims to explore the impact of curcumin supplementation on oxidative stress and exercise performance in Wistar rats.
Twenty-eight male Wistar rats were used and divided into four groups: control, control + curcumin, control + exercise, and control + exercise + curcumin.
Curcumin was administered at a dose of 100 mg/kg for 6 weeks, and exercise protocols were implemented over 5 days of increased treadmill activity.
Blood and muscle samples were analyzed for levels of oxidative stress, antioxidant markers, and muscle proteins.
Lactate and muscle malondialdehyde levels significantly decreased in curcumin-treated groups (P<0.0001).
Antioxidant enzyme activities increased in curcumin-treated groups, indicating improved oxidative stress response.
Muscle NF-kB and heat shock protein 70 levels were significantly lower in the curcumin-treated group compared to exercise only (P<0.05).

Juturu et al. (2016) studied this question.

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Randomized trial investigates curcumin's role in reducing muscle damage and improving exercise performance in rats, suggesting dietary interventions.