Key result
Hypertension is linked to selective reductions in circulating regulatory and exhausted T-cell subsets.
Observational
Reveals decreased anti-inflammatory T cells in hypertension, suggesting immune involvement.
Evidence from nonhuman animal models demonstrates an important role for immune cells in hypertension, but immune cell changes in human hypertension are less clear. Using mass cytometry, we demonstrate novel and selective reductions in CCR10+ regulatory T cells (Tregs) and PD-1+CD57−CD8+ memory T cells. RNA sequencing reveals that CCR10+ Tregs exhibit gene expression changes consistent with enhanced immunosuppressive function. In addition, CITE-Seq demonstrates that PD-1+CD57−CD8+ memory T cells exhibit features of T-cell exhaustion. Taken together, these results provide novel evidence for decreases in anti-inflammatory and/or hypofunctional T-cell populations that may contribute to enhanced inflammation in human hypertension.
No takes yet. Share an insight, caveat, or question.
Alexander et al. (2023) conducted an observational in Hypertension. Hypertension was evaluated on Levels of circulating regulatory and exhausted T cells (CCR10+ Tregs and PD-1+CD57-CD8+ memory T cells). Human hypertension is associated with selective decreases in circulating CCR10+ regulatory T cells and exhausted PD-1+CD57-CD8+ memory T cells, potentially contributing to enhanced inflammation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: