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In vitro model investigates macrophage polarization in hematopoietic stem/progenitor cells, suggesting new insights into immune responses.
The article describes a readily easy adaptive in vitro model to investigate macrophage polarization. In the presence of GM-CSF/M-CSF, hematopoietic stem/progenitor cells from the bone marrow are directed into monocytic differentiation, followed by M1 or M2 stimulation. The activation status can be tracked by changes in cell surface antigens, gene expression and cell signaling pathways.
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Ying et al. (2013) studied this question.
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