Key result
Normal weight patients presented higher rates of in-hospital bleeding complications and lower survival after a STEMI compared to overweight patients (p=0.041).
Why the study?
STEMI remains a major cause of mortality, and tailoring individual management by considering patient specificities may improve survival.
Does body mass index impact in-hospital bleeding complications and survival in patients with STEMI?
Cohort (n=2,070)
Does body mass index impact in-hospital bleeding complications and survival in patients with STEMI?
p-value: p=0.041
Normal weight patients with STEMI may have higher rates of in-hospital bleeding and lower survival compared to overweight patients, suggesting an obesity paradox related to bleeding vulnerability.
Higher bleeding rates in normal-weight STEMI patients may drive excess mortality; leaves open BMI-tailored bleeding prevention strategies.
BACKGROUND: ST-elevation myocardial infarction (STEMI) remains a major cause of mortality despite early revascularization and optimal medical therapy. Tailoring individual management by considering patients' specificities may help in improving post-STEMI survival. AIM: To evaluate whether in-hospital bleeding complications may be involved in post STEMI prognosis among overweight patients. METHODS: We prospectively included 2070 patients with a STEMI between January 2005 and December 2012 in the French observational cohort, "Registre d'Infarctus Maine-Anjou". Bleeding Academic Research Consortium (BARC) in-hospital bleeding complications were recorded. RESULTS: = 0.041). CONCLUSION: Normal weight patients presented higher rates of in-hospital bleeding complications and lower survival after a STEMI. Excess mortality might be due to greater vulnerability to bleeding amongst normal weight patients.
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Ingremeau et al. (2019) conducted a cohort in ST-elevation myocardial infarction (STEMI) (n=2,070). Normal weight vs. Overweight was evaluated on In-hospital bleeding complications (BARC) and survival (p=0.041). Normal weight patients presented higher rates of in-hospital bleeding complications and lower survival after a STEMI compared to overweight patients (p=0.041).
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