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June 28, 2026Analytical Chemistry

Single-Particle Isotopic Analysis Using the Liquid Sampling-Atmospheric Pressure Glow Discharge Microplasma Coupled to an Orbitrap Mass Spectrometer

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Authors

SSSuraj ShresthaSSSarah E. SzakasHAHunter B. Andrews

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Overview

Randomized trial demonstrates effective isotopic analysis of individual particles, indicating improved measurement accuracy.

Key Points

  • The aim is to present a method for single-particle isotopic analysis improving upon conventional techniques.
  • Isotope ratio determinations were conducted on single CeO2 microparticles using LS-APGD microplasma coupled to Orbitrap mass spectrometer.
  • The analysis was performed at a mass resolution of approximately 330,000 for CeO2 microparticles.
  • Isotopic accuracy was validated through comparison with SP-ICP-TOF-MS analysis.
  • Achieved a detection limit of 2.9 fg for 142Ce.
  • The method yielded a relative difference of approximately 1.4% from the particle digest ratio.
  • The isotopic accuracy and precision were in good agreement with an established SP-ICP-TOF-MS method.

Cite This Study

Shrestha et al. (2026) studied this question.

synapsesocial.com/papers/6a40b92b61bb0a67205c577bhttps://doi.org/10.1021/acs.analchem.6c02718
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