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June 28, 2026iScienceOpen Access

Global landscape of liver disease burden in 1990–2021

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Authors

MZM ZhangLMLijie MaWJWeiqiu Jin

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Overview

Global burden of liver diseases increased significantly, with regional disparities highlighting urgent health needs.

Key Points

  • To analyze the worldwide burden of liver diseases and identify trends from 1990 to 2021.
  • Utilized Global Burden of Disease 2021 data to assess liver disease impact.
  • Applied a framework linking total liver diseases to specific conditions such as hepatitis and liver cancer.
  • Examined trends across different regions, age, and sex demographics.
  • Liver diseases were responsible for 309.72 million new cases and 1.98 million deaths in 2021.
  • High-income regions saw increased death and DALY rates, particularly from alcohol and steatosis-related liver diseases.
  • Projected rise in liver cancer cases, specifically due to steatohepatitis and hepatoblastoma.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a40b92b61bb0a67205c57d6https://doi.org/10.1016/j.isci.2026.116406
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