Case report shows ovarian hyperstimulation induced by FSH-secreting adenoma, suggesting surgery as treatment.
BACKGROUND: Functional gonadotropic adenoma is a rare pituitary adenoma. Only a few cases have been reported. CASE PRESENTATION: Herein, we describe the case of a 30-year-old Chinese woman with functional gonadotroph adenomas (FGAs) with relative hyperprolactinemia and no obvious neurologic signs. Ovarian hyperstimulation due to a follicle-stimulating hormone (FSH)-secreting adenoma was observed after treatment with a gonadotropin-releasing hormone analogue (GnRH-a). The patient was successfully treated through pituitary adenomectomy and experienced a successful pregnancy after in vitro fertilization (IVF). CONCLUSION: Our report suggests that a patient showing ovarian hyperstimulation related to an FSH-secreting adenoma may present with high PRL and estradiol levels and indicates that transsphenoidal surgery should be the first choice for treatment.
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Lu et al. (2026) studied this question.
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