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June 28, 2026Journal of Adaptive Medical Immunology and Public Health Issues

Features of the microbial landscape of the skin of patients with atopic dermatitis during exacerbation and in the remission phase

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Authors

ЕЛЕ.А. ЛевковаPeoples' Friendship University of RussiaЕБЕ. А. БородулинаMinistry of Health of the Russian FederationVDV.V. DmitrievaPeoples' Friendship University of Russia

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Implication

Randomized trial investigates skin microbiota changes in atopic dermatitis during exacerbation and remission, highlighting treatment implications.

Key Points

  • The study aims to analyze the skin's microbial profile in atopic dermatitis during exacerbation and remission phases.
  • Examined 46 patients with moderate-severe atopic dermatitis and frequent exacerbations (≥3 episodes per year).
  • Skin microbiota analyzed using blood agar and mass spectrometry for blood samples.
  • Severity assessed with SCORAD index.
  • During exacerbation, high levels of Staphylococcus aureus (6±0.76×106) and Escherichia coli (7±0.83×107) were observed on the skin.
  • Increased presence of herpes simplex virus types 1 and 2 and cytomegalovirus also detected in the blood during exacerbation.
  • Remission phase showed prevalence of saprophytic staphylococci and normal levels of herpesviruses.

Cite This Study

Левкова et al. (2026) studied this question.

synapsesocial.com/papers/6a40ba2161bb0a67205c6184https://doi.org/10.17116/immunology2026201160
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence and Incidence of Atopic Dermatitis: A Systematic Review2020 · 512 citations
  2. 2European Guideline ( EuroGuiDerm ) on atopic eczema: Living update2025 · 82 citations
  3. 3Severity Scoring of Atopic Dermatitis: The SCORAD Index2009 · 2,323 citations
  4. 4Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis2012 · 1,836 citations
  5. 5Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis2019 · 293 citations