Demonstrates effective silylation in alkenylphosphine oxides, highlighting new synthetic methods.
A general method for enantioselective silylation of both aromatic and aliphatic α,β-unsaturated phosphine oxide derivatives remains elusive. Herein, we report a versatile enantioselective conjugate silylation protocol enabled by a newly developed N-heterocyclic carbenes. Under copper(I)–YC-NHC7 catalysis, a wide range of aromatic and aliphatic alkenylphosphine oxides undergoes efficient conjugate silylation, affording structurally diverse β-silylated alkylphosphine oxide derivatives with moderate to high yields and enantioselectivities.
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Huang et al. (2026) studied this question.
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